Beilstein J. Org. Chem.2022,18, 374–380, doi:10.3762/bjoc.18.42
polyhydroxylated steroids lobophysterols E–H (1–4), together with three known compounds (5–7), were isolated from the soft coral Lobophytumpauciflorum collected at Xisha Island, China. The structures of the new compounds were elucidated by extensive spectroscopic analysis and comparison with NMR data of
addition, compound 1 also showed a moderate anti-inflammatory effect in zebrafish.
Keywords: anti-inflammatory; cytotoxicity; Lobophytumpauciflorum; soft coral; steroids; X-ray diffraction; Introduction
The unique and complicated marine environment makes soft corals a treasure-house of secondary
investigated the chemical constituents of the soft coral Lobophytumpauciflorum, collected from Xisha Island in the South China Sea. In the present paper, we describe the isolation of four new polyhydroxylated steroids lobophysterols E–H (1–4), together with three known compounds (5–7) (Figure 1). The